UreaPro Information For Physicians

UreaPro has the same safety and efficacy of ure-Na which is used in top American hospitals, but with added affordability for outpatient use.

Mechanism of Action of urea for the treatment of hyponatremia

Urea normalizes serum sodium by inducing osmotic excretion of free water without associated electrolyte depletion. Urea also ameliorates hyponatremia in SIADH by a more specific effect, diminishing the natriuresis in association with increased medullary urea content.

European renal best practice guidelines for the treatment of SIADH

7.4.3. Patients with SAIDH  In moderate or profound hyponatremia, we suggest restricting fluid intake as a first-line-treatment (2D). In moderate or profound hyponatremia, we suggest the following can be considered equal second-line treatments: a) Increasing solute intake with 0.25–0.50g/kg per day if urea or a combination of low dose loop diuretics and oral sodium chloride (2D). In moderate or profound hyponatremia, we recommend against lithium or demeclocycline (1D).  In moderate hyponatremia, we do not recommend vasopressin receptor antagonists (1C).  In profound hyponatremia, we recommend against vasopressin receptor antagonists (1C).


UreaPro dosing chart based on the European Guidelines.

mOsm comparison of urea vs. NaCl

1 - 15 gram scoop of UreaPro equals 250 mOsm, equal to 14.7 500mg NaCl tablets or 7.35 1g NaCl tablets.

2 - 15 gram scoops of UreaPro contains 30g of urea and equals 500 mOsm, equal to 29.4 500mg NaCl tablets or 14.7 1g NaCl tablets.

Patients not appropriate for UreaPro

Click below to view a presentation on the clinical data for the use of urea for the outpatient management of hyponatremia.



November 2018 CJASN published clinical study on the use of ure-Na to treat hyponatremia in the inpatient setting. 


ASN Kidney News editorial featuring our sister product ure-Na


UreaPro and BUN

Urea is produced normally in the body by the liver. As such, it is considered safe (GRAS designation by the FDA), and does not carry nephrotoxic or hepatotoxic potential. Since the blood test for BUN measures Blood Urea Nitrogen levels, it is expected that when UreaPro is administered, an increase in BUN levels may be seen. However, this isolated increase in not indicative of kidney function, and is similar to what may be seen when individuals consume a high protein diet with production of additional amounts of urea by the liver.

UreaPro should be used under medical supervision with close monitoring of laboratory studies.

UreaPro Ingredients

Ingredients in descending order:

  • Synthetically derived urea powder
  • Silica
  • Calcium Silicate

UreaPro with 30 doses and 15g per dose.

A resealable pouch of UreaPro contains 30 15 gram doses of urea that has been stabilized to reduce clumping. Inside the pouch is a scoop with that offers 15 g urea.

Unlike ure-Na, UreaPro will have to be flavored. Patients can find flavoring recipies in the Patient page of ureapro.com